The Peale family is best known as a family of artists; however, family interests and activities were much more wide-ranging. The best known Peale is Charles Willson Peale (1741-1827, APS 1786), who produced more than one thousand paintings, including hundreds of portraits of leading Americans during the colonial and early national periods. Peale was married three times, to Rachel Brewster (1744-1790), Elizabeth de Peyster (1765-1804), and Hannah More (1755-1821). He had eighteen children, eleven of whom reached adulthood. Three of Charles Willson Peale's sons became artists: Raphaelle Peale (1774-1825), Rembrandt Peale (1778-1860), and Rubens Peale (1784-1865). A fourth son, Titian Ramsay Peale (1799-1885, APS 1833), was a naturalist (who made drawings on the exploring expeditions he accompanied) and pioneer in photography, and another son, Benjamin Franklin Peale (1795-1870), became a naturalist and paleontologist. Peale's daughter Sophonisba Angusciola was married to Coleman Sellers (1781-1834), an inventor and manufacturer of machinery, including locomotives. Two of their sons, George Escol Sellers (1808-1899) and Coleman Sellers (1827-1907, APS 1872), were inventors and engineers. The latter served as director of the construction of the hydro-electric power development at Niagara Falls. He was married to Cornelia Wells Sellers (1831-1909). One of their grandsons was Charles Coleman Sellers (1903-1980, APS 1979), a librarian and historian and the author of several studies of the Peale family, including a Charles Willson Peale biography.

A collection of letters, legal papers and financial records of three generations of the prominent Philadelphia family. Spanning 1745-1955, detailed are the legal cases and political advocacy work of John Kintzing Kane (1795-1858), Robert Patterson Kane (1827-1906), and Francis Fisher Kane (1866-1955). Also includes correspondence, architectural drawings, and photograph albums of the Cope family. Robert Patterson Kane's daughter Eliza Middleton Kane (1863-1952) married the Philadelphia architect Walter Cope (1860-1902) in 1893. The APS papers of Elisha Kent Kane are in call no. B K132.

The son of William Franklin, Royal Governor of New Jersey, William Temple Franklin worked as aide to his grandfather, Benjamin Franklin, when the latter served as minister to France during the American Revolution. A bonvivant, Temple received his highest public appointment as Secretary to the American delegation at the Treaty of Versailles in 1782-1783, largely through the influence of his famous grandfather, but never again attained a significant post. As Franklin's literary heir, he edited and published a three volume set of his grandfather's writings in 1817. He married his long time mistress a few months before his death in Paris in 1823. The William Temple Franklin Papers provides a richly detailed portrait of the life of the grandson of Benjamin Franklin, and consists largely of letters received during the years that Temple served as his grandfather's aide in France, 1776-1785. Although much of the correspondence is routine, during this period, Temple received regular reports from friends and diplomatic colleagues relaying information on the American Revolution, the course of diplomatic and peace negotiations, and French public opinion on Benjamin Franklin and the new United States. The collection is also a rich resource for information on the personal lives of the Franklins, including interesting correspondence from Temple's relatives William Franklin, Elizabeth Franklin, Sarah Franklin Bache, and Jonathan Williams, and his mistress Blanchette Caillot.